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Title Due Date Maximum Award Amount Description
Advanced Development and Validation of Emerging Molecular and Cellular Analysis Technologies for Basic and Clinical Cancer Research (R33 Clinical Trial Not Allowed) Varies

This Funding Opportunity Announcement (FOA) solicits grant applications proposing exploratory research projects focused on further development and validation of emerging technologies offering novel capabilities for targeting, probing, or assessing molecular and cellular features of cancer biology for basic or clinical cancer research. This FOA solicits R33 applications where major feasibility gaps for the technology or methodology have been overcome, as demonstrated with supportive preliminary data, but still requires further development and rigorous validation to encourage adoption by the research community. Well-suited applications must offer the potential to accelerate and/or enhance research in the areas of cancer biology, early detection and screening, clinical diagnosis, treatment, control, epidemiology, and/or address issues associated with cancer health disparities. Technologies proposed for development may be intended to have widespread applicability but must be focused on improving molecular and/or cellular characterizations of cancer. Projects proposing application of existing technologies where the novelty resides in the biological or clinical target/question being pursued are not appropriate for this solicitation and will not be reviewed.This funding opportunity is part of a broader NCI-sponsored Innovative Molecular Analysis Technologies (IMAT) Program.

https://www.grants.gov/web/grants/view-opportunity.html?oppId=344756
Innovative Biospecimen Science Technologies for Basic and Clinical Cancer Research (R61 Clinical Trial Not Allowed) Varies

This Funding Opportunity Announcement (FOA) solicits grant applications proposing exploratory research projects focused on the early-stage development of highly innovative technologies that improve the quality of the samples used for cancer research or clinical care. This includes new capabilities to address issues related to pre-analytical degradation of targeted analytes during the collection, processing, handling, and/or storage of cancer-relevant biospecimens. The overall goal is to support the development of highly innovative technologies capable of maximizing or otherwise interrogating the quality and utility of biological samples used for downstream analyses. This FOA will support the development of tools, devices, instrumentation, and associated methods to preserve or protect sample integrity, or establish verification criteria for quality assessment/quality control and handling under diverse conditions. These technologies are expected to accelerate and/or enhance research in cancer biology, early detection and screening, clinical diagnosis, treatment, epidemiology, or address issues associated with cancer health disparities, by reducing pre-analytical variations that affect biospecimen sample quality.This funding opportunity is part of a broader NCI-sponsored Innovative Molecular Analysis Technologies (IMAT) Program.

https://www.grants.gov/web/grants/view-opportunity.html?oppId=344757
NOAA SBIR FY 2023 Phase I $175,000.00

The Department of Commerce (DOC) National Oceanic and Atmospheric Administration (NOAA) invites small businesses to submit research proposals under this NOFO. Firms with the capability to conduct research and development (R&D) in any of the research topic areas listed in Section 9.0 of this announcement and to commercialize the results of that R&D are encouraged to participate. The Small Business Innovation Research (SBIR) Program is not a substitute for existing unsolicited proposal mechanisms. Unsolicited proposals are not accepted under the SBIR program. Only FY 2023 Phase I applications may be submitted in response to this NOFO. Phase II applications are not being accepted at this time. NOAA will publish a Phase II NOFO approximately 30 days prior to the end of the previous year’s Phase I period of performance to request Phase II applications. That NOFO will provide instructions for Phase I awardees to prepare a Phase II application and the closing date for submission of applications; only the previous year’s Phase I awardees are eligible to submit a Phase II application. The Small Business Innovation Research (SBIR) program was originally established in 1982 by the Small Business Innovation Development Act (P.L. 97-219), codified at 15 U.S.C. § 638. It was then expanded and extended by the Small Business Research and Development Enhancement Act of 1992 (P.L. 102-564), and received subsequent reauthorization and extensions, the most recent of which extends the SBIR program through 2025. (P.L. 117-183). Each Federal agency with an extramural budget for research/research and Development (R/R&D) in excess of $100,000,000 must participate in the SBIR program and spend (obligate) a minimum percentage of their extramural R/R&D budgets (obligations) of not less than 3.2% of such budget in fiscal year 2017 and for the percentage required by statute for each fiscal year after for awards to small business concerns (SBCs) for R/R&D under the SBIR program. The objectives of the SBIR program are to: stimulate technological innovation in the private sector; strengthen the role of small business in meeting Federal R&D needs; foster and encourage participation by businesses owned by socially and economically disadvantaged persons and women-owned SBCs in technological innovation; and increase private sector commercialization of innovations derived from federal R&D funding. Fostering diversity by encouraging the participation of individuals from nationally underrepresented groups in the scientific research workforce is longstanding interest of Congress, and a key component of NOAA’s commitment to diversity, equity, inclusion, and accessibility (e.g., Public Law 114-329, American Innovation and Competitiveness Act of 2017, and https://tpo-dev.oar.woc.noaa.gov/abouttpo/dei-statement/). Increasing participation by socially and economically disadvantaged and women-owned small businesses is critical to the success of the SBIR program.

https://www.grants.gov/web/grants/view-opportunity.html?oppId=344747
Alumni Engagement Innovation Fund (AEIF) 2023 $35,000.00

AEIF provides alumni of U.S. government-sponsored and -facilitated exchange programs with funding to expand on skills gained during their exchange experience to design and implement innovative solutions to global challenges facing their community. Since its inception in 2011, AEIF has funded nearly 500 alumni-led projects around the world through a competitive global competition. This year, AEIF 2023 will support the United States’ commitment to improve good governance and help Guatemala become more prosperous and more secure.The U.S. Embassy in Guatemala will review public service projects proposed and managed by teams composed of at least two (2) alumni that support themes such as:· Promoting free and credible elections· Promoting the rule of law and ethics, transparency and anticorruption· Protecting and supporting human rights· Improving equitable access to education for youth, especially from regions marked by high rates of irregular migration· Promoting greater, more equitable access to justice· Promoting business knowledge and training for entrepreneurs

https://www.grants.gov/web/grants/view-opportunity.html?oppId=344751
2023 HERO Appendix A: NASA Human Research Program Omnibus Opportunity $150,000.00

New NASA Research Announcement NNJ21ZSA001N-OMNIBUS NASA Human Research Program Omnibus Opportunity NASA’s Human Research Program (HRP) has released solicited research response area NRA NNJ23ZSA001N-OMNIBUS “NASA Human Research Program Omnibus Opportunity” that solicits applied research in support of HRP goals and objectives. This response area is Appendix A of the Human Exploration Research Opportunities (HERO) NRA (NNJ23ZSA001N). NASA is soliciting investigations lasting no more than one year that provide innovative approaches to any of the risks and gaps contained in the Integrated Research Plan (https://humanresearchroadmap.nasa.gov) of the Human Research Program. NASA is also soliciting novel research ideas that might not be directly aligned with HRP’s identified risks from new investigators or early career investigators who have not received funding from NASA HRP, NASA Established Program to Stimulate Competitive Research, the National Space Biomedical Research Institute, or the Translational Research Institute for Space Health in the last ten years. Early career investigators must additionally be no more than ten years from their terminal research degree or clinical training. Proposals will be reviewed using a dual-anonymous peer review (DAPR) process in which the identity of reviewers will not be shared with proposers and the identity of proposers will not be shared with reviewers until after the technical merit has been evaluated for all anonymized proposals. See the solicitation for details on preparing proposals. Appendix A of the HERO NRA and associated documentation can be found at: https://tinyurl.com/HERO23-OMNIBUS. The HERO NRA including all open appendices is available through the NASA Research Opportunities homepage at: https://tinyurl.com/HERO23OVERVIEW. A virtual Pre-Proposers Conference is scheduled for December 13, 2022, at 10:30 AM ET, and more details are posted alongside this solicitation on NSPIRES. Appendix A Step-1 proposals are due January 6, 2023. Invited Appendix A Step-2 proposals are due April 4, 2023. All categories of United States (U.S.) institutions are eligible to submit proposals in response to the NRA. Principal Investigators may collaborate with universities, Federal Government laboratories, the private sector, and state and local government laboratories. In all such arrangements, the applying entity is expected to be responsible for administering the project according to the management approach presented in the proposal. NASA’s policy is to conduct research with non-U.S. organizations on a cooperative, no exchange-of-funds basis.

https://www.grants.gov/web/grants/view-opportunity.html?oppId=344738
U.S. Embassy Honduras - PAS Notice of Funding Opportunity $35,000.00

The U.S. Embassy Honduras Public Affairs Section (PAS) of the U.S. Department of State is pleased to announce an open competition for organizations and individuals to submit applications to carry out a program or project through its Public Diplomacy Small Grants Program. This is a Notice of Funding Opportunity outlining our funding priorities, strategic themes, and procedures for submitting requests for funding. Please carefully follow all instructions below. Submissions that do not adhere to these instructions will not be considered. The Public Affairs Section is particularly interested in projects that support creating opportunities that allow Hondurans to build their futures in Honduras. Preference will be given to proposals that demonstrate the long-term sustainability of the project, in-kind and/or in-cash financial commitments from other funding sources, and impact evaluation components. Priority Program Areas: PAS Honduras invites proposals that: · Support inclusive and sustainable economic growth (priority: projects that revive the economy during and after the global pandemic, improve the business climate, or promote entrepreneurship, innovation, and equitable access to economic opportunities); · Promote press freedom and counter disinformation (priority: programs that combat disinformation or promote press freedom, strengthen investigative journalism capacity, and improve transparency); · Increase transparency, rule of law, and civic engagement (priority: projects that support anticorruption efforts, facilitate non-partisan democracy or voter education programming, or strengthen civil society); · Empower underserved communities and promote respect for human rights (priority: projects that promote equal rights and opportunities for women, LGBTI+ individuals, people with disabilities, indigenous communities, and racial minorities, as well as implement civic education); · Improve access to quality education, including English language learning (priority: projects that provide resources and skills in education technology and innovation to reach public school teachers/students, higher education professors/students, young professionals, or communities in key economic growth areas); and/or · Develop climate resilience and food and water security (priority: projects that implement civic education on climate mitigation or facilitate subject matter expert exchanges on agricultural innovation) · Build long-term relationships between U.S. and Honduran higher education institutions. PLEASE NOTE: All programs must include a clear connection to the United States, such as an American cultural element or participation of an American expert(s), organization(s), or institution(s), in order to promote increased understanding of U.S. policy and perspectives. Please see full announcement attached for details.

https://www.grants.gov/web/grants/view-opportunity.html?oppId=344739
ROSES 2022: High Priority Open-Source Science Varies

This program element does not have a proposal due date. Proposals may be submitted at any time, pending certain eligibility timing issues related to resubmissions and duplicate proposal avoidance (see the program element text and appropriate overview appendix (e.g., B.1 or C.1)). The date shown of 3/29/2023 is the last day that proposals may be submitted subject to the ROSES-22 rules and the current Guidebook for Proposers. The ROSES-23 version of this program element is planned to overlap with this ROSES-22 version by a few weeks, allowing continuous submission of proposals across ROSES years. Proposers must retrieve the instructions document (zip file) associated with the application package for this opportunity as there is at least one required form that must be attached to the submitted proposal package. The National Aeronautics and Space Administration (NASA) Science Mission Directorate (SMD) released its annual omnibus Research Announcement (NRA), Research Opportunities in Space and Earth Sciences (ROSES) – 2022 (OMB Approval Number 2700-0092, CFDA Number 43.001) on February 14, 2022. In this case "omnibus" means that this NRA has many individual program elements, each with its own due dates and topics. All together these cover the wide range of basic and applied supporting research and technology in space and Earth sciences supported by SMD. Awards will be made as grants, cooperative agreements, contracts, and inter- or intra-agency transfers, depending on the nature of the work proposed, the proposing organization, and/or program requirements. However, most extramural research awards deriving from ROSES will be grants, and many program elements of ROSES specifically exclude contracts, because contracts would not be appropriate for the nature of the work solicited. The typical period of performance for an award is three years, but some programs may allow up to five years and others specify shorter periods. In most cases, organizations of every type, Government and private, for profit and not-for-profit, domestic and foreign (with some caveats), may submit proposals without restriction on teaming arrangements. Tables listing the program elements and due dates, the full text of the ROSES-2022 solicitation, and the "Summary of Solicitation" as a stand-alone document, may all be found NSPIRES at http://solicitation.nasaprs.com/ROSES2022. This synopsis is associated with one of the individual program elements within ROSES, but this is a generic summary that is posted for all ROSES elements. For specific information on this particular program element download and read the PDF of the text of this program element by going to Tables 2 or 3 of this NRA at http://solicitation.nasaprs.com/ROSES2022table2 and http://solicitation.nasaprs.com/ROSES2022table3, respectively, click the title of the program element of interest, a hypertext link will take you to a page for that particular program element. On that page, on the right side under "Announcement Documents" the link on the bottom will be to the PDF of the text of the call for proposals. For example, if one were interested in The Lunar Data Analysis Program (NNH22ZDA001N-LDAP) one would follow the link to the NSPIRES page for that program element and then to read the text of the call one would click on “C.8 Lunar Data Analysis (.PDF)” to download the text of the call. If one wanted to set it into the context of the goals, objectives and know the default rules for all elements within Appendix C, the planetary science division, one might download and read “C.1 Planetary Science Research Program Overview (.PDF)” from that same page. While the letters and numbers are different for each element within ROSES (A.12, B.7, etc.) the basic configuration is always the same, e.g., the letter indicates the Science Division (A is Earth Science, B is Heliophysics etc.) and whatever the letter, #1 is always the division overview. Frequently asked questions for ROSES are posted at http://science.nasa.gov/researchers/sara/faqs. Questions concerning general ROSES-2022 policies and procedures may be directed to Max Bernstein, Lead for Research, Science Mission Directorate, at sara@nasa.gov, but technical questions concerning specific program elements should be directed to the point(s) of contact for that particular element, who may be found either at the end of the individual program element in the summary table of key information or on the web list of topics and points of contact at: http://science.nasa.gov/researchers/sara/program-officers-list. Not all program elements are known at the time of the release of ROSES. To be informed of new program elements or amendments to this NRA, proposers may subscribe to: (1) The SMD mailing lists (by logging in at http://nspires.nasaprs.com and checking the appropriate boxes under "Account Management" and "Email Subscriptions"), (2) The ROSES-2022 RSS feed for amendments, clarifications, and corrections to at http://science.nasa.gov/researchers/sara/grant-solicitations/ROSES-2022, and (3) The ROSES-2022 due date Google calendars (one for each science division). Instructions are at https://science.nasa.gov/researchers/sara/library-and-useful-links (link from the words due date calendar).

https://www.grants.gov/web/grants/view-opportunity.html?oppId=344736
2023 Human Exploration Research Opportunities (HERO) Overview Varies

NASA Human Exploration Research Opportunities (HERO) Released A National Aeronautics and Space Administration (NASA) Research Announcement (NRA), entitled, “Human Exploration Research Opportunities (HERO)” (NNJ21ZSA001N), has been released. This NRA will solicit applied research in support of NASA’s Human Research Program (HRP). This NRA is available through the NASA Research Opportunities homepage at: https://tinyurl.com/HERO23OVERVIEW. The research will fall into one or more categories corresponding to HRP’s five Elements: Space Radiation, Human Health Countermeasures, Exploration Medical Capability, Human Factors and Behavioral Performance, and Research Operations and Integration. This NRA covers all aspects of research to provide human health and performance countermeasures, knowledge, technologies, and tools to enable safe, reliable, and productive human space exploration. Awards generally range from under $150K per year for focused, limited efforts (e.g., data analysis) to $1M per year for extensive activities (e.g., development of scientific hardware) and will be made as grants. The funds available for awards in each research opportunity offered in this NRA range from less than one million to several million dollars. This range allows selection from a few to as many as a dozen proposals depending on the program objectives and the submission of proposals of merit. The period of performance for an award can range from one to five years. All categories of United States (U.S.) institutions are eligible to submit proposals in response to this NRA. Any changes or modifications to any of these guidelines will be specified in the descriptions of the relevant research opportunities in the solicited research response area appendices of this solicitation. Details of the topics will be given in the solicited research response area appendices of the NRA. Unless otherwise specified, appendices will use a two-step solicitation process requiring that a compliant and relevant Step-1 proposal be submitted in order to be considered to be invited to submit a Step-2 proposal. Proposals will, unless otherwise specified, be reviewed using a dual-anonymous peer review (DAPR) process in which the identity of reviewers will not be shared with proposers and the identity of proposers will not be shared with reviewers until after the technical merit has been evaluated for all anonymized proposals. Proposal due dates will be staggered throughout the HERO open period of November 30, 2022 to November 29, 2023. The first proposal due date (for Step-1 proposals submitted in response to Appendix A) is January 6, 2023. The electronic submission of each is required by the due date for proposal submission. Proposal due dates are given in the NRA and the solicited research response area appendices, which will be posted at https://nspires.nasaprs.com. Interested proposers should monitor https://nspires.nasaprs.com or register and subscribe to the Human Exploration and Operations Mission Directorate (HEOMD) electronic notifications system through the NASA Solicitation and Proposal Integrated Review and Evaluation System (NSPIRES) account subscription services. New program elements or amendments to this NRA through November 2023 will be posted in NSPIRES, after which time release of a subsequent HERO NRA is planned. All categories of United States (U.S.) institutions are eligible to submit proposals in response to the NRA. Principal Investigators may collaborate with universities, Federal Government laboratories, the private sector, and state and local government laboratories. In all such arrangements, the applying entity is expected to be responsible for administering the project according to the management approach presented in the proposal. NASA’s policy is to conduct research with non-U.S. organizations on a cooperative, no exchange-of-funds basis.

https://www.grants.gov/web/grants/view-opportunity.html?oppId=344737
Distance Learning and Telemedicine Grants $1,000,000.00

Authorized by 7 U.S.C. 950aaa, the DLT Program provides financial assistance to enable and improve distance learning and telemedicine services in rural areas. DLT grant funds support the use of telecommunications-enabled information, audio and video equipment, and related advanced technologies by students, teachers, medical professionals, and rural residents. These grants are intended to increase rural access to education, training, and health care resources that are otherwise unavailable or limited in scope.The regulation for the DLT Program can be found at 7 CFR part 1734. All applicants should carefully review and prepare their applications according to instructions in the FY 2023 DLT Grant Program Application Guide (Application Guide) and program resources. This Application Guide will be made available here and on the program website at https://www.rd.usda.gov/programs-services/distance-learning-telemedicin…. Expenses incurred in developing applications will be at the applicant’s own risk.

https://www.grants.gov/web/grants/view-opportunity.html?oppId=344731
Integrative Computational Tools for Systems Biology Research $1,050,000.00

The BER program supports basic research to understand the fundamental nature of biological processes relevant to DOE energy and environmental mission goals. Within BER, the GSP supports systems biology research on microbial, plant, plant-microbe interactions, and environmental microbial communities to address DOE’s mission in sustainable bioenergy development. Understanding and harnessing the metabolic and regulatory networks of plants and microbes will enable their design and re-engineering for improved energy resilience and sustainability, including advanced biofuels and bio products. The widespread adoption of high-throughput, multi-omic techniques has revolutionized biological research, enabling a broader view and deeper understanding of cellular processes and the biological systems they drive. In pursuit of predictive modeling and genome-scale engineering of complex biological systems important for bioenergy, the research supported by the GSP generates vast amounts of complex omic’ and other data from a wide range of analytical technologies and experimental approaches. These data span multiple spatio-temporal scales, reflecting the organizational complexities of biological systems, and present significant computational challenges for identifying causal variants that influence phenotype. Accurate modeling of the underlying systems biology depends on surmounting those challenges.The collective characterization and quantification of pools of biological molecules (genomics, transcriptomics, proteomics, metabolomics) and their systems processes are essential to construct coherent knowledge of the systems underpinning and governing the diverse phenomics and functioning of plants, microbes, and their communities. Such characterizations necessitate the ability to combine data sets of heterogeneous types, integrated over time and space, and to represent emergent relationships in a coherent framework.The breadth of data types and the complexities inherent in the integration of different data layers present significant conceptual and implementation challenges. New algorithms for incorporating data derived from innovations in genomics, molecular imaging, structural biology, and spectroscopy are needed to work effectively with, and glean useful insights from, complex, integrated molecular, -omics’ data. Computational simulation and rigorous hypothesis testing depend on the ability to incorporate multiple experimental/environmental conditions and associated meta-datasets.Through this FOA, BSSD solicits applications that propose innovative computational solutions that can integrate large, disparate data types from multiple and varied sources, and/or the integration of data to achieve coordinated knowledge or integration of knowledge to decipher relationships of biological systems of relevance to DOE. Novel computational tools and analytical approaches of large-scale, multimodal, and multiscale data that will lead to scalable solutions for omics analysis, data mining, and knowledge extraction from complex data sets (experimental and calculated) are sought. Bioinformatics tools or computational applications that are interoperable and effective for computationally intensive data processing and analyses for systems-level investigations are desirable. Also encouraged is the enhancement of existing software or approaches that are demonstrated to be in broad use by the genomics community, to aid the interpretation of multimodal data for environmental sciences.

https://www.grants.gov/web/grants/view-opportunity.html?oppId=344733