Funding Wizard

The EHDA supports the initial exploration of innovative, high-risk, high-gain, and potentially groundbreaking concepts in the TSC research field. The studies supported by this award mechanism are expected to generate preliminary data for future avenues of scientific investigation. The proposed research project should include a well-formulated, testable hypothesis based on a strong scientific rationale and study design. Applications should demonstrate the ability to achieve interpretable results in the absence of preliminary data supporting the hypothesis. The following are important aspects of the EHDA: · Innovation: Innovative research may introduce a new paradigm, challenge existing paradigms, examine existing problems from new perspectives, or exhibit other highly creative qualities. Research that is an incremental advance upon published data is not considered innovative and is not consistent with the intent of the award mechanism. Although not all-inclusive, the following examples are ways in which the proposed research project may be innovative: ○ Explores a novel idea and/or research question in TSC research and/or patient care. ○ Uses or develops novel methods or technologies to address a question in TSC research and/or patient care. ○ Applies or adapts existing methods or technologies for novel TSC research or clinical purposes that differ fundamentally from those originally intended.

This Agreement establishes a strategic working relationship between NPS and The Conservation Fund (TCF), whose variety of community focused services related to merging economic and conservation goals provides valuable expertise for advancing Gateways Network and Chesapeake conservation and restoration goals. The TCF, through its Conservation Leadership Network (CLN) and the Conservation Finance Network (CFN), will be a key near- and long-term partner in support of NPS efforts to advance land conservation. The CLN provides services focused on collaborative problem-solving --bringing people together to facilitate on-the-ground results related to conservation and community development. The CFN advances land and resource conservation by expanding the use of innovative and effective funding and financing strategies.THIS ANNOUNCEMENT IS NOT A REQUEST FOR APPLICATIONS. This announcement is to provide public notice of the National Park Service’s intention to award financial assistance. Detailed statements of work will be defined at the task agreement level based on the goals, objectives, and public purpose of this agreement.

Eligibility for the program listed in this NOFO is open to all domestic non-Federal entities. Eligible applicants include accredited institutions of higher education; non-profit organizations; for-profit organizations incorporated in the United States; and state, local, territorial, and Indian tribal governments. Please note that individuals and unincorporated sole proprietors are not considered “non-Federal entities” and are not eligible to apply under this NOFO. Although Federal entities are not eligible to receive funding under this NOFO, they may participate as unfunded collaborators.

Wetland Program Development Grants (WPDGs) assist state, territorial, tribal, local government agencies and interstate/intertribal entities in developing or refining state/ territorial/tribal/local programs which protect, manage, and restore wetlands. The primary focus of these grants is to develop/refine state, territorial, and tribal wetland programs. A secondary focus is to develop/refine local (e.g. county or municipal) programs.

The FY21 RTRP Advanced Technology Development Award is intended to support research critical for the translation of promising preclinical findings into products focused on reconstructive transplantation. Important aspects of this award mechanism include: • Study Design and Feasibility: The proposed study design should be clearly described, rigorous, well-integrated, and support maximal reproducibility and translational feasibility. A statistical plan with appropriate power analysis should be included, if applicable. It should be clear how the proposed study design of this project will position the product for the next phase of development as described in the post-award Transition Plan (Attachment 9). • Impact/Military Relevance: The short- and long-term impact of the proposed research should be clearly articulated. Projects must address at least one of the FY21 RTRP Advanced Technology Development Award Focus Areas listed in Section II.A.1 above. All products to be developed should be responsive to the healthcare needs of military Service Members and/or Veterans recovering from traumatic injury, and/or their family members, caregivers, or clinicians, as well as the general public. Collaboration with military and VA researchers and clinicians is encouraged but not required. • Transition Plan: The post-award Transition Plan (Attachment 9) should include potential funding and resources and show how the product will progress to the next level of development (e.g., clinical trials, delivery to the military or civilian market) after the successful completion of this award. A regulatory strategy as applicable to the proposed research/product should also be included. • Preliminary Data: Proof of concept demonstrating potential utility of the proposed product, or a prototype/preliminary version of the proposed product, must already be established. Preliminary and/or published data that are relevant to reconstructive transplantation, and that support the rationale for the proposed study, must be included (these data may be unpublished if from a member of the research team, or from the published literature). Proposed research and products to be developed may be materiel products such as drugs, biologic agents, or devices, or knowledge-based products such as technical reports and clinical practice guidelines that inform clinical/operational decisions and promote evidence-based changes in clinical practice and standard of care. Proposed research may include animal research and/or human subjects research, as appropriate; however, clinical trials are not allowed under this funding opportunity.

RFI: Technology Advancements for Subsurface Exploration for Renewable Energy Resources or Carbon Storage This is a Request for Information (RFI) only. This RFI is not soliciting application for financial assistance. The purpose of this RFI is solely to solicit input for ARPA-E consideration to inform the possible formulation of future programs. The purpose of this RFI is to solicit input for a potential future ARPA-E research program focused on technologies that enable high-resolution, wide-area subsurface mapping in order to identify opportunities for renewable energy technologies and the future low-carbon economy. Examples where advances in subsurface imaging will be critical include, but are not limited to, locating reservoirs for carbon capture and storage (CCS), identifying new geothermal sites, mapping natural accumulations of energy-relevant minerals, and assessing potential resources of geologic hydrogen. The goal is to better understand how subsurface imaging technologies today may need to expand, adapt, or improve beyond technologies which have been optimized for oil and gas exploration. ARPA-E is seeking information at this time regarding the state of the art in subsurface imaging technologies and transformative and implementable technologies that could: 1. Reduce frontier exploration costs for renewable energy or carbon storage projects by an order of magnitude or more, leveraging advancements in subsurface imaging, data collection, and data processing. For new renewable technologies or CCS projects, identifying potential geologic sites with the requisite properties requires honing in on sites from a much larger region, often in areas that have not been traditionally explored by oil and gas interests and where there is little prior high-quality imaging data. Isolating regions of interest could mean developing new, cost-effective wide-area subsurface exploration technologies, using a combination of imaging techniques paired with multi-physics models, using data processing or novel geostatistical methods to upgrade or augment existing datasets, and/or developing machine learning algorithms which can fill in data gaps. 2. Advance data processing to accommodate larger amounts of data and reduce processing time by orders of magnitude for wide-area and/or nationwide subsurface imaging surveys. 3. Dramatically improve project success rates. Successful technologies would result in outcomes such as reduced incidence of dry wells in geothermal energy projects or identification of new energy-relevant mineral deposits. These outcomes can be facilitated by acquiring higher-quality and/or more comprehensive data in order to discern sites with high probability factors. 4. Monitor dynamic changes in the subsurface over time (4D mapping) with more sensitive surveys techniques, more comprehensive models, and/or algorithms. ARPA-E expects that subsurface changes of interest to renewable energy or CCS projects (e.g. changes in rock morphology, active water-rock chemical reactions, fluid migration, fracture network development, biological processes) may be different than those typically modelled for the oil and gas industry and that current models may need to be expanded to include these processes. 5. Reveal opportunities for interdisciplinary collaboration, combining the expertise of groups that traditionally do not interact, in order to gain a more comprehensive understanding of dynamic geologic processes. To view the RFI in its entirety, please visit https://arpa-e-foa.energy.gov. The information you provide may be used by ARPA-E in support of program planning. THIS IS A REQUEST FOR INFORMATION ONLY. THIS NOTICE DOES NOT CONSTITUTE A FUNDING OPPORTUNITY ANNOUNCEMENT (FOA). NO FOA EXISTS AT THIS TIME.

The FY22 PCARP Translational Research Partnership Award supports partnerships between clinicians and research scientists that will accelerate the movement of promising ideas in pancreatic cancer toward clinical applications. This award supports the development of translational research collaborations between two independent investigators to address a central problem or question in pancreatic cancer in a manner that would be less readily achievable through separate efforts. One partner in the collaboration must function as a research scientist and the other partner as a clinician investigator. It should be clear that both have had equal intellectual input in the design of the research project. Projects involving convergence science partnerships are strongly encouraged. At least one partner must have expertise either in pancreatic cancer research or pancreatic cancer patient care. Inclusion of experts from outside the pancreatic cancer field is encouraged. A proposed project in which the clinical partner merely supplies tissue samples or access to patients will not meet the intent of this award mechanism. Full support for large-scale clinical trials is not expected; retrospective tissue analysis, correlative studies, or small pilot clinical trials are permitted. Significant features of the Translational Research Partnership Award: · Partnership: The success of the project should depend on the unique skills and contributions of each partner. · Translation: The application should provide evidence for the reciprocal transfer of information between basic and clinical science, or vice versa, in developing and implementing the research plan. Translational research may include correlative studies and/or development of or use of annotated biorepositories. The application should demonstrate how the study will leverage clinical information to address knowledge gaps in resulting outcomes, validate key research findings, expand upon potentially transformative results, and/or investigate novel findings. · Impact: The proposed research should indicate the potential to have a significant impact on pancreatic cancer research and/or patient care and have the potential to accelerate the movement of promising ideas (in prevention, diagnosis, detection, prognosis, treatment, and/or survivorship) into clinical applications. · Feasibility: The application should demonstrate that the investigators have access to the necessary specimens, data, and/or intervention, as applicable. · Preliminary Data: Published and/or unpublished results from the laboratory of the Principal Investigators (PIs) or collaborators named on the application that are relevant to pancreatic cancer and the proposed research project, are required. Preliminary data to support the feasibility of the research hypothesis(es) and research approaches are required; however, these data do not necessarily need to be derived from studies of pancreatic cancer. Observations that drive a research idea may be derived from a laboratory discovery, population-based studies, or a clinician’s firsthand knowledge of patients and anecdotal data. The ultimate goal of translational research is to move a concept or observation forward into clinical application that is relevant to active duty Service Members, Veterans, other military beneficiaries, and the American public. However, translational research should not be viewed as a one-way continuum from bench to bedside. The research plan must involve a reciprocal flow of ideas and information between basic and clinical science. There should be an intellectual synergistic partnership between the clinic and the laboratory. The success of the project must be supported by the unique skills and contributions of each partner. The proposed study must include clearly stated plans for interactions between the PIs and the institutions involved. The plans must include communication, coordination of research progress and results, and data transfer. Additionally, multi-institutional applications must provide an intellectual property plan to resolve potential intellectual and material property issues and to remove institutional barriers that might interfere with achieving high levels of cooperation to ensure the successful completion of this award. The Translational Research Partnership Award requires two PIs. One will be identified as the Initiating PI and will be responsible for the majority of the administrative tasks associated with application submission. The other will be identified as a Partnering PI. Both PIs should contribute significantly to the development of the proposed research project, including the Project Narrative, Statement of Work (SOW), and other required components. If recommended for funding, each PI will be named to an individual award within the recipient organization. For individual submission requirements for the Initiating and Partnering PIs, refer to Section II.D.2, Content and Form of the Application Submission. It is the responsibility of the PIs to describe how their combined expertise will better address the research question and explain why the work should be done together rather than through separate efforts.

The Exploration - Hypothesis Development Research Award supports the initial exploration of innovative, high-risk, high-gain, and potentially groundbreaking concepts in the MS research field. The studies supported by this award mechanism are expected to lay the groundwork for future avenues of scientific investigation. The proposed research project should include a well-formulated, testable hypothesis based on strong scientific rationale and study design. The presentation of preliminary and/or published data is not required. The proposed research project must be innovative. Innovative research may examine a novel paradigm, challenge current paradigms, look at existing problems from novel perspectives, or exhibit other highly creative qualities. Research that is an incremental advance beyond ongoing research and published data is not considered innovative and is not consistent with the intent of this award mechanism. It is the responsibility of the Principal Investigator (PI) to clearly and explicitly articulate how the proposed research project is innovative in the field of MS research.

The Community Assistance Program - State Support Services element (CAP-SSSE) program provides funding to States to provide technical assistance to communities in the National Flood Insurance Program (NFIP) and to evaluate community performance in implementing NFIP floodplain management activities. Designation, duties, and responsibilities of State Coordinating Agencies are found in 44 CFR 60.25. These regulations identify the states commitment to the minimum floodplain management criteria and to demonstrate the capability and responsibility to implement the program. In this way, CAP-SSSE helps to; ensure that the flood loss reduction goals of the NFIP are met, build state and community floodplain management expertise and capability, and leverage state knowledge and expertise in working with their communities.

The H6 program seeks to develop ultra-small, low-power, fieldable clocks that can maintain their timing precision for one week.