Title Due Date Maximum Award Amount Description
BRAIN Initiative: Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R61 Basic Experimental Studies with Humans Required) Varies

Invasive surgical procedures offer the opportunity for unique intracranial interventions such as the ability to record and stimulate intracranially within precisely localized brain structures in humans. Human studies using invasive technology are often constrained by a limited number of patients and resources available to implement complex experimental protocols and need to be aggregated in a manner that addresses research questions with appropriate statistical power. Therefore, this RFA seeks applications to assemble diverse, integrated, multi-disciplinary teams that cross boundaries of interdisciplinary collaboration to overcome these fundamental barriers and to investigate high-impact questions in human neuroscience. The research should be offered as exploratory research and planning activities to establish feasibility, proof-of-principle and early-stage development that, if successful, would support, enable, and/or lay the groundwork for a potential, subsequent Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain, as described in the companion FOA (RFA-NS-22-041). Projects should maximize opportunities to conduct innovative in vivo neuroscience research made available by direct access to the brain from invasive surgical procedures. Projects should employ approaches guided by specified theoretical constructs and by quantitative, mechanistic models where appropriate. Awardees will join a consortium working group, coordinated by the NIH, to identify consensus standards of practice, including neuroethical considerations, to collect and provide data for ancillary studies, and to aggregate and standardize data for dissemination among the wider scientific community.
BRAIN Initiative Fellows: Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (F32) Varies

The purpose of the The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative Fellows (F32) program is to enhance the research training of promising postdoctorates, early in their postdoctoral training period, who have the potential to become productive investigators in research areas that will advance the goals of the BRAIN Initiative. Applications are encouraged in any research area that is aligned with the BRAIN Initiative, including neuroethics. Applicants are expected to propose research training in an area that clearly complements their predoctoral research. Formal training in analytical tools appropriate for the proposed research is expected to be an integral component of the research training plan. In order to maximize the training potential of the F32 award, this program encourages applications from individuals who have not yet completed their terminal doctoral degree and who expect to do so within 12 months of the application due date. On the application due date, candidates may not have completed more than 12 months of postdoctoral training.
BRAIN Initiative: Brain Behavior Quantification and Synchronization Data Coordination and Artificial Intelligence Center (U24 Clinical Trial Optional) Varies

This funding opportunity announcement (FOA) invites applications for creating the Data Coordination and Artificial Intelligence Center (DCAIC) for the Brain Behavior Quantification and Synchronization (BBQS) Consortium of the BRAIN Initiative. The FOA will support a single award to a multi-disciplinary team with a single or multiple PIs working on the five interrelated areas:1) Data Management; 2) Data Standards; 3) ML/AI Resources; 4) Data Ecosystem; and 5) Dissemination, Training and Coordination.
Liver Cancer Collaborative Projects with the Liver Cirrhosis Network (U01 Clinical Trial Optional) $200,000.00

Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) intends to establish collaborations between liver cancer investigators and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)-funded Liver Cirrhosis Network (LCN) members to advance our understanding of hepatocellular carcinoma (HCC) as the result of liver cirrhosis and its etiologic risks, development, progression, early diagnosis, and treatment. The funds available through this FOA will support new multidisciplinary liver cancer-specific collaborations between eligible liver cancer investigators and one or more of the NIDDK-funded LCN members. This structure is intended to maximize the effectiveness of the network by facilitating collaborative opportunities that enhance the scientific goals of the collaborating units and the LCN as a whole. Applicants selected for NCI funding will become members of the Liver Cirrhosis Network-Liver Cancer Collaboratory (LCN-LCa) Committee.
Request for Applications (RFA): Revision Applications to Support Research on Prevention and Cessation of Menthol Cigarette Use in Populations that Experience Health Disparities (R01, Clinical Trial Optional) $200,000.00

As part of the ADVANCE: Advancing Prevention Research for Health Equity program, the NIH Office of Disease Prevention (ODP) within the Office of the Director Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI) is soliciting revision applications (formerly called "competitive revisions") to active R01 grants to support studies that develop and evaluate menthol cigarette smoking cessation and prevention interventions for populations that experience health disparities.
Impacts of climate change across the cancer control continuum (R21 Clinical Trial Optional) $275,000.00

Through this funding opportunity announcement, the National Cancer Institute (NCI) intends to focus on the impacts of climate change across the cancer control continuum (R01 Clinical Trial Optional)
Impacts of climate change across the cancer control continuum (R01 Clinical Trial Optional) Varies

Through this funding opportunity announcement, the National Cancer Institute (NCI) intends to focus on the impacts of climate change across the cancer control continuum (R01 Clinical Trial Optional)

DE-FOA-0003048, SBIR/STTR Grid Overhaul with Proactive, High-speed Undergrounding for Reliability, Resilience, and Security (GOPHURRS) To obtain a copy of the Funding Opportunity Announcement (FOA) please go to the ARPA-E website at To apply to this FOA, Applicants must register with and submit application materials through ARPA-E eXCHANGE ( For detailed guidance on using ARPA-E eXCHANGE, please refer to the ARPA-E eXCHANGE User Guide ( ARPA-E will not review or consider concept papers submitted through other means. For problems with ARPA-E eXCHANGE, email (with FOA name and number in the subject line). Questions about this FOA? Check the Frequently Asked Questions available at For questions that have not already been answered, email Agency Overview: The Advanced Research Projects Agency – Energy (ARPA-E), an organization within the Department of Energy (DOE), is chartered by Congress in the America COMPETES Act of 2007 (P.L. 110-69), as amended by the America COMPETES Reauthorization Act of 2010 (P.L. 111-358), as further amended by the Energy Act of 2020 (P.L. 116-260): “(A) to enhance the economic and energy security of the United States through the development of energy technologies that— (i) reduce imports of energy from foreign sources; (ii) reduce energy-related emissions, including greenhouse gases; (iii) improve the energy efficiency of all economic sectors; (iv) provide transformative solutions to improve the management, clean-up, and disposal of radioactive waste and spent nuclear fuel; and (v) improve the resilience, reliability, and security of infrastructure to produce, deliver, and store energy; and (B) to ensure that the United States maintains a technological lead in developing and deploying advanced energy technologies.” ARPA-E issues this Funding Opportunity Announcement (FOA) under its authorizing statute codified at 42 U.S.C. § 16538. The FOA and any cooperative agreements or grants made under this FOA are subject to 2 C.F.R. Part 200 as supplemented by 2 C.F.R. Part 910. ARPA-E funds research on, and the development of, transformative science and technology solutions to address the energy and environmental missions of the Department. The agency focuses on technologies that can be meaningfully advanced with a modest investment over a defined period of time in order to catalyze the translation from scientific discovery to early-stage technology. For the latest news and information about ARPA-E, its programs and the research projects currently supported, see: ARPA-E funds transformational research. Existing energy technologies generally progress on established “learning curves” where refinements to a technology and the economies of scale that accrue as manufacturing and distribution develop drive improvements to the cost/performance metric in a gradual fashion. This continual improvement of a technology is important to its increased commercial deployment and is appropriately the focus of the private sector or the applied technology offices within DOE. By contrast, ARPA-E supports transformative research that has the potential to create fundamentally new learning curves. ARPA-E technology projects typically start with cost/performance estimates well above the level of an incumbent technology. Given the high risk inherent in these projects, many will fail to progress, but some may succeed in generating a new learning curve with a projected cost/performance metric that is significantly better than that of the incumbent technology. ARPA-E funds technology with the potential to be disruptive in the marketplace. The mere creation of a new learning curve does not ensure market penetration. Rather, the ultimate value of a technology is determined by the marketplace, and impactful technologies ultimately become disruptive – that is, they are widely adopted and displace existing technologies from the marketplace or create entirely new markets. ARPA-E understands that definitive proof of market disruption takes time, particularly for energy technologies. Therefore, ARPA-E funds the development of technologies that, if technically successful, have clear disruptive potential, e.g., by demonstrating capability for manufacturing at competitive cost and deployment at scale. ARPA-E funds applied research and development. The Office of Management and Budget defines “applied research” as an “original investigation undertaken in order to acquire new knowledge…directed primarily towards a specific practical aim or objective” and defines “experimental development” as “creative and systematic work, drawing on knowledge gained from research and practical experience, which is directed at producing new products or processes or improving existing products or processes.” Applicants interested in receiving financial assistance for basic research (defined by the Office of Management and Budget as “experimental or theoretical work undertaken primarily to acquire new knowledge of the underlying foundations of phenomena and observable facts”) should contact the DOE’s Office of Science ( Office of Science national scientific user facilities ( are open to all researchers, including ARPA-E Applicants and awardees. These facilities provide advanced tools of modern science including accelerators, colliders, supercomputers, light sources and neutron sources, as well as facilities for studying the nanoworld, the environment, and the atmosphere. Projects focused on early-stage R&D for the improvement of technology along defined roadmaps may be more appropriate for support through the DOE applied energy offices including: the Office of Energy Efficiency and Renewable Energy (, the Office of Fossil Energy and Carbon Management (, the Office of Nuclear Energy (, and the Office of Electricity ( Program Overview: GOPHURRS (Grid Overhaul with Proactive, High-Speed Undergrounding for Reliability, Resilience, and Security) intends to fund a portfolio of new technologies based on bold and unconventional ideas that will transform the construction of underground medium voltage (MV, 5 – 46 kV) power distribution grids (e.g., primary feeders and laterals) in urban and suburban areas and reduce the cost of undergrounding electric power grids by at least 50% in order to improve the overall reliability, resilience, and security of power infrastructure in the United States. SAIDI (System Average Interruption Duration Index) and SAIFI (System Average Interruption Frequency Index) are two commonly used reliability metrics. In the United States today, SAIDI and SAIFI range approximately 5-8 hours and 1.5 times per customer, respectively, which is responsible for an economic cost to U.S. electricity consumers of $79 billion/year. Undergrounding powerlines is a proven way of improving the system reliability for both transmission and distribution grids as indicated in stark differences in SAIDI and SAIFI of overhead systems and underground systems (Figure 1). Despite the reliability benefits, the cost of burying distribution powerlines is significant, up to five to ten times that of overhead distribution lines, making it the major barrier to making such grid investment decisions. Furthermore, today's undergrounding processes pose safety concerns, such as damage to other buried utilities during construction, occupational safety and health hazards associated with tasks performed in a manhole, and lengthy surface disruptions and traffic detours affecting the safety of surrounding communities, making undergrounding a difficult project to undertake. The GOPHURRS program aims to reduce the time and cost required to underground by a factor of at least two when compared to traditional trenching-based methods. More specifically, GOPHURRS technologies will shift the paradigm of undergrounding from digging to drilling in order to leave the surface nearly untouched. In order to achieve this goal, GOPHURRS focuses on developing transformative technologies capable of achieving autonomous/trenchless utility installation, such as automated and rapid subsurface drilling along the terrain and concurrent conduit installation, while also avoiding hidden underground obstacles (e.g., existing infrastructure, geologic anomalies) with advanced look-ahead sensors (Figure 2). In addition, GOPHURRS aims to reduce the life cycle cost of an underground power system by developing reliable cable joint designs and installation systems, as cable joints are typically the first to fail during operation. The GOPHURRS program could reduce costs, increase speed, and improve the reliability and safety of undergrounding operations and the surrounding communities by developing such technologies focused on automation, damage prevention, and error elimination. To view the FOA in its entirety, please visit
Office of Postsecondary Education (OPE): International Foreign Language Education (IFLE): International Research and Studies Program—Research, Studies and Surveys; and Specialized Instructional Materials, Assistance Listing Number 84.017A Varies

Note: Each funding opportunity description is a synopsis of information in the Federal Register application notice. For specific information about eligibility, please see the official application notice. The official version of this document is the document published in the Federal Register. Free Internet access to the official edition of the Federal Register and the Code of Federal Regulations is available on GPO Access at: Please review the official application notice for pre-application and application requirements, application submission information, performance measures, priorities and program contact information. For the addresses for obtaining and submitting an application, please refer to our Revised Common Instructions for Applicants to Department of Education Discretionary Grant Programs, published in the Federal Register on December 7, 2022. Purpose of Program: The IRS program provides grants to public and private agencies, organizations, institutions, and individuals, to conduct research, studies, or surveys, or to develop specialized instructional materials, to improve and strengthen instruction and enrollment in modern foreign languages and related area studies. Under 34 CFR 660.1, research and studies may include, but are not limited to - (a) Studies and surveys to determine needs for increased or improved instruction in modern foreign languages, area studies, or other international fields, including the demand for foreign language, area studies, and other international specialists in government, education, and the private sector; (b) Research on more effective methods of providing instruction and achieving competency in foreign languages, area studies, or other international fields; (c) Research on applying performance tests and standards across all areas of foreign language instruction and classroom use; (d) Developing and publishing specialized materials for use in foreign language, area studies, and other international fields or for training foreign language, area studies, and other international specialists; (e) Studies and surveys to assess the use of graduates of programs supported under title VI of the Higher Education Act of 1965, as amended (HEA) by governmental, educational, and private-sector organizations and other studies assessing the outcomes and effectiveness of supported programs; (f) Comparative studies of the effectiveness of strategies to provide international capabilities at institutions of higher education; (g) Evaluations of the extent to which programs assisted under title VI of the HEA that address national needs would not otherwise be offered; (h) Studies and surveys of the use of technologies in foreign language, area studies, and international studies programs; (i) Studies and evaluations of effective practices in the dissemination of international information, materials, research, teaching strategies, and testing techniques throughout the educational community, including elementary and secondary schools; (j) Evaluations of the extent to which programs assisted under title VI of the HEA reflect diverse perspectives and a wide range of views and generate debate on world regions and international affairs; (k) Systematic collection, analysis, and dissemination of data that contribute to achieving the purposes of title VI, part A of the HEA; and (l) Support for programs or activities to make data collected, analyzed, or disseminated under this part publicly available and easy to understand. In this competition, applicants may request support for either a Research, Studies, or Surveys Project or a Specialized Instructional Materials Project. In section 15 of the SF 424 Application for Federal Assistance, applicants must clearly identify the type of IRS project for which funding is requested. Additional submission details are included in the application package. Assistance Listing Number (ALN) 84.017A.
Discovery and Development of Natural Products for Cancer Interception and Prevention (UG3/UH3 Clinical Trial Not Allowed) $250,000.00

The overall goal of this UG3/UH3 Exploratory/Developmental phased initiative is to support the discovery and development of novel natural products that are safe, nontoxic, and efficacious for cancer interception and prevention. 1. Purpose of UG3: Select clinically relevant targets and develop and validate assays for bioactivity as well as toxicity screening 2. Purpose of UH3 phase: Screening libraries, structure elucidation, full-scale characterization, efficacy testing, and development of the screened agents.